What actually helps male fertility?
The short answer
The best-supported steps for men are lifestyle ones: stop smoking, keep cool, keep alcohol moderate, and get a semen analysis early. Supplements haven't held up — two good trials found no benefit.
What to know
- Sperm take about two to three months to develop, so changes now show up later.
- Testosterone and anabolic steroids switch off sperm production.
- Folic acid and zinc didn't improve births or sperm quality in a trial of 2,370 couples.
- A multi-antioxidant supplement didn't help either.
- Any abnormal semen analysis should lead to a male fertility specialist.
Read the full explanation
What actually helps
- Get a semen analysis early. Both partners should be evaluated together, and any abnormal result should lead to a visit with a male fertility specialist (a reproductive urologist).
- Stop smoking. It lowers sperm count and movement.
- Keep things cool: loose underwear, fewer long stretches of sitting, and no hot tubs or saunas while you're trying.
- Keep alcohol moderate. In couples doing IVF, men drinking more than about six drinks a week had lower live birth rates.
- Move toward a healthy weight, and exercise if you're mostly sedentary.
- Give it time. Sperm take about two to three months to develop, so changes made now show up in a semen analysis a few months later.
The evidence for each of these is modest, but they're low-cost, good for your health, and the ones the urology guideline recommends.
Be careful
Safety consideration Testosterone and anabolic steroids switch off sperm production. The US urology guideline says men who want children, now or later, shouldn't be prescribed testosterone. If you take it, tell your doctor before you start trying — recovery can take months.
What about supplements?
The two best trials were both negative. In FAZST (2,370 couples), folic acid and zinc didn't improve live births or sperm quality, and sperm DNA damage was slightly higher on the supplement. In MOXI (171 couples), a multi-antioxidant formula didn't improve sperm, and live births were lower (15% vs 24%) before the trial stopped early. The urology guideline calls supplements "of questionable clinical utility."
What the research shows
Does folic acid and zinc supplementation in male partners improve live birth rates?
This was studied properly, and it did not show the benefit people expect. That's a finding, not a gap.
Who was studied. 2,370 couples in a randomized, double-blind, placebo-controlled trial - men presenting for infertility treatment.
Outcome measured. Live birth
What was found. No. Supplementation did not improve live birth rates, and did not improve semen quality either. It did increase gastrointestinal side effects.
Main limitation. None significant — a large, well-designed trial with a clear negative result.
Why this rating?
Large, randomized, double-blind, placebo-controlled, with live birth as the outcome. This is about as strong as fertility evidence gets, and it is a clear negative result.
Questions for your doctor
Edit any of these before you add it — they're yours. Your list stays in this browser, and you can print a one-page sheet from it.
- Is there a specific finding on my partner's semen analysis that a supplement would target?
- What has actually been shown to help in our situation?
Sources
- AUA/ASRM Guideline, Diagnosis and treatment of infertility in men (2020, amended 2024)
- Schisterman et al., Folic acid and zinc in men (FAZST randomized trial), JAMA 2020
- NICHD, Antioxidants do not improve male fertility (MOXI trial), 2020
- ASRM, Tobacco or marijuana use and infertility: a committee opinion
- Rao et al., Alcohol, caffeine and IVF outcomes: systematic review and meta-analysis, 2022