Onward Babe

What actually helps male fertility?

The short answer

The best-supported steps for men are lifestyle ones: stop smoking, keep cool, keep alcohol moderate, and get a semen analysis early. Supplements haven't held up — two good trials found no benefit.

What to know

  • Sperm take about two to three months to develop, so changes now show up later.
  • Testosterone and anabolic steroids switch off sperm production.
  • Folic acid and zinc didn't improve births or sperm quality in a trial of 2,370 couples.
  • A multi-antioxidant supplement didn't help either.
  • Any abnormal semen analysis should lead to a male fertility specialist.
Safety and interactions. More nausea and abdominal discomfort in the supplement group than on placebo.
Read the full explanation

What actually helps

  • Get a semen analysis early. Both partners should be evaluated together, and any abnormal result should lead to a visit with a male fertility specialist (a reproductive urologist).
  • Stop smoking. It lowers sperm count and movement.
  • Keep things cool: loose underwear, fewer long stretches of sitting, and no hot tubs or saunas while you're trying.
  • Keep alcohol moderate. In couples doing IVF, men drinking more than about six drinks a week had lower live birth rates.
  • Move toward a healthy weight, and exercise if you're mostly sedentary.
  • Give it time. Sperm take about two to three months to develop, so changes made now show up in a semen analysis a few months later.

The evidence for each of these is modest, but they're low-cost, good for your health, and the ones the urology guideline recommends.

Be careful

Safety consideration Testosterone and anabolic steroids switch off sperm production. The US urology guideline says men who want children, now or later, shouldn't be prescribed testosterone. If you take it, tell your doctor before you start trying — recovery can take months.

What about supplements?

The two best trials were both negative. In FAZST (2,370 couples), folic acid and zinc didn't improve live births or sperm quality, and sperm DNA damage was slightly higher on the supplement. In MOXI (171 couples), a multi-antioxidant formula didn't improve sperm, and live births were lower (15% vs 24%) before the trial stopped early. The urology guideline calls supplements "of questionable clinical utility."

What the research shows

Does folic acid and zinc supplementation in male partners improve live birth rates?

Strong evidence Recommended against

This was studied properly, and it did not show the benefit people expect. That's a finding, not a gap.

Who was studied. 2,370 couples in a randomized, double-blind, placebo-controlled trial - men presenting for infertility treatment.

Outcome measured. Live birth

What was found. No. Supplementation did not improve live birth rates, and did not improve semen quality either. It did increase gastrointestinal side effects.

Main limitation. None significant — a large, well-designed trial with a clear negative result.

Why this rating?

Large, randomized, double-blind, placebo-controlled, with live birth as the outcome. This is about as strong as fertility evidence gets, and it is a clear negative result.

Questions for your doctor

Edit any of these before you add it — they're yours. Your list stays in this browser, and you can print a one-page sheet from it.

  • Is there a specific finding on my partner's semen analysis that a supplement would target?
  • What has actually been shown to help in our situation?

Sources

Editorial status. Written and edited September 2026 · every citation on this page opened and checked against the claim it supports, September 2026 · not reviewed by a clinician. We say that plainly because it matters: this is researched and sourced writing, not a medically reviewed publication. Take it to someone who knows your history.
Onward Babe is educational, not medical advice. Everything here is built from published research and professional guidelines so you can have a better conversation with the doctor who actually knows your situation.